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Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides

CBASS is a common anti-phage immune system that uses cyclic oligonucleotide signals to activate effectors and limit phage replication. In turn, phages encode anti-CBASS (Acb) proteins. We recently uncovered a widespread phage anti-CBASS protein Acb2 that acts as a “sponge” by forming a hexamer compl...

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Detalles Bibliográficos
Autores principales: Cao, Xueli, Xiao, Yu, Huiting, Erin, Cao, Xujun, Li, Dong, Ren, Jie, Guan, Linlin, Wang, Yu, Li, Lingyin, Bondy-Denomy, Joseph, Feng, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312549/
https://www.ncbi.nlm.nih.gov/pubmed/37398474
http://dx.doi.org/10.1101/2023.06.01.543220