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Visual deprivation during mouse critical period reorganizes network-level functional connectivity
A classic example of experience-dependent plasticity is ocular dominance (OD) shift, in which the responsiveness of neurons in the visual cortex is profoundly altered following monocular deprivation (MD). It has been postulated that OD shifts also modify global neural networks, but such effects have...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312598/ https://www.ncbi.nlm.nih.gov/pubmed/37398380 http://dx.doi.org/10.1101/2023.05.30.542957 |
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author | Chen, Siyu Rahn, Rachel M. Bice, Annie R. Bice, Seana H. Hengen, Keith B. Dougherty, Joseph D. Culver, Joseph P. |
author_facet | Chen, Siyu Rahn, Rachel M. Bice, Annie R. Bice, Seana H. Hengen, Keith B. Dougherty, Joseph D. Culver, Joseph P. |
author_sort | Chen, Siyu |
collection | PubMed |
description | A classic example of experience-dependent plasticity is ocular dominance (OD) shift, in which the responsiveness of neurons in the visual cortex is profoundly altered following monocular deprivation (MD). It has been postulated that OD shifts also modify global neural networks, but such effects have never been demonstrated. Here, we used longitudinal wide-field optical calcium imaging to measure resting-state functional connectivity during acute (3-day) MD in mice. First, delta GCaMP6 power in the deprived visual cortex decreased, suggesting that excitatory activity was reduced in the region. In parallel, interhemispheric visual homotopic functional connectivity was rapidly reduced by the disruption of visual drive through MD and was sustained significantly below baseline state. This reduction of visual homotopic connectivity was accompanied by a reduction in parietal and motor homotopic connectivity. Finally, we observed enhanced internetwork connectivity between visual and parietal cortex that peaked at MD2. Together, these findings support the hypothesis that early MD induces dynamic reorganization of disparate functional networks including association cortices. |
format | Online Article Text |
id | pubmed-10312598 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cold Spring Harbor Laboratory |
record_format | MEDLINE/PubMed |
spelling | pubmed-103125982023-07-01 Visual deprivation during mouse critical period reorganizes network-level functional connectivity Chen, Siyu Rahn, Rachel M. Bice, Annie R. Bice, Seana H. Hengen, Keith B. Dougherty, Joseph D. Culver, Joseph P. bioRxiv Article A classic example of experience-dependent plasticity is ocular dominance (OD) shift, in which the responsiveness of neurons in the visual cortex is profoundly altered following monocular deprivation (MD). It has been postulated that OD shifts also modify global neural networks, but such effects have never been demonstrated. Here, we used longitudinal wide-field optical calcium imaging to measure resting-state functional connectivity during acute (3-day) MD in mice. First, delta GCaMP6 power in the deprived visual cortex decreased, suggesting that excitatory activity was reduced in the region. In parallel, interhemispheric visual homotopic functional connectivity was rapidly reduced by the disruption of visual drive through MD and was sustained significantly below baseline state. This reduction of visual homotopic connectivity was accompanied by a reduction in parietal and motor homotopic connectivity. Finally, we observed enhanced internetwork connectivity between visual and parietal cortex that peaked at MD2. Together, these findings support the hypothesis that early MD induces dynamic reorganization of disparate functional networks including association cortices. Cold Spring Harbor Laboratory 2023-05-30 /pmc/articles/PMC10312598/ /pubmed/37398380 http://dx.doi.org/10.1101/2023.05.30.542957 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator. |
spellingShingle | Article Chen, Siyu Rahn, Rachel M. Bice, Annie R. Bice, Seana H. Hengen, Keith B. Dougherty, Joseph D. Culver, Joseph P. Visual deprivation during mouse critical period reorganizes network-level functional connectivity |
title | Visual deprivation during mouse critical period reorganizes network-level functional connectivity |
title_full | Visual deprivation during mouse critical period reorganizes network-level functional connectivity |
title_fullStr | Visual deprivation during mouse critical period reorganizes network-level functional connectivity |
title_full_unstemmed | Visual deprivation during mouse critical period reorganizes network-level functional connectivity |
title_short | Visual deprivation during mouse critical period reorganizes network-level functional connectivity |
title_sort | visual deprivation during mouse critical period reorganizes network-level functional connectivity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312598/ https://www.ncbi.nlm.nih.gov/pubmed/37398380 http://dx.doi.org/10.1101/2023.05.30.542957 |
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