De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8

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The RGD (Arg-Gly-Asp)-binding integrins αvβ6 and αvβ8 are clinically validated cancer and fibrosis targets of considerable therapeutic importance. Compounds that can discriminate between the two closely related integrin proteins and other RGD integrins, stabilize specific conformational states, and...

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Detalles Bibliográficos
Autores principales: Roy, Anindya, Shi, Lei, Chang, Ashley, Dong, Xianchi, Fernandez, Andres, Kraft, John C., Li, Jing, Le, Viet Q., Winegar, Rebecca Viazzo, Cherf, Gerald Maxwell, Slocum, Dean, Daniel Poulson, P., Casper, Garrett E., Vallecillo-Zúniga, Mary L., Valdoz, Jonard Corpuz, Miranda, Marcos C., Bai, Hua, Kipnis, Yakov, Olshefsky, Audrey, Priya, Tanu, Carter, Lauren, Ravichandran, Rashmi, Chow, Cameron M., Johnson, Max R., Cheng, Suna, Smith, McKaela, Overed-Sayer, Catherine, Finch, Donna K., Lowe, David, Bera, Asim K., Matute-Bello, Gustavo, Birkland, Timothy P, DiMaio, Frank, Raghu, Ganesh, Cochran, Jennifer R., Stewart, Lance J., Campbell, Melody G., Van Ry, Pam M., Springer, Timothy, Baker, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312613/
https://www.ncbi.nlm.nih.gov/pubmed/37398153
http://dx.doi.org/10.1101/2023.06.12.544624
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