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Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and regeneration

Muscular atrophy is a mortality risk factor that happens with disuse, chronic disease, and aging. Recovery from atrophy requires changes in several cell types including muscle fibers, and satellite and immune cells. Here we show that Zfp697/ZNF697 is a damage-induced regulator of muscle regeneration...

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Autores principales: Correia, Jorge C., Jannig, Paulo R., Gosztyla, Maya L., Cervenka, Igor, Ducommun, Serge, Præstholm, Stine M., Dumont, Kyle, Liu, Zhengye, Liang, Qishan, Edsgärd, Daniel, Emanuelsson, Olof, Gregorevic, Paul, Westerblad, Håkan, Venckunas, Tomas, Brazaitis, Marius, Kamandulis, Sigitas, Lanner, Johanna T., Yeo, Gene W., Ruas, Jorge L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312635/
https://www.ncbi.nlm.nih.gov/pubmed/37398033
http://dx.doi.org/10.1101/2023.06.12.544338
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author Correia, Jorge C.
Jannig, Paulo R.
Gosztyla, Maya L.
Cervenka, Igor
Ducommun, Serge
Præstholm, Stine M.
Dumont, Kyle
Liu, Zhengye
Liang, Qishan
Edsgärd, Daniel
Emanuelsson, Olof
Gregorevic, Paul
Westerblad, Håkan
Venckunas, Tomas
Brazaitis, Marius
Kamandulis, Sigitas
Lanner, Johanna T.
Yeo, Gene W.
Ruas, Jorge L.
author_facet Correia, Jorge C.
Jannig, Paulo R.
Gosztyla, Maya L.
Cervenka, Igor
Ducommun, Serge
Præstholm, Stine M.
Dumont, Kyle
Liu, Zhengye
Liang, Qishan
Edsgärd, Daniel
Emanuelsson, Olof
Gregorevic, Paul
Westerblad, Håkan
Venckunas, Tomas
Brazaitis, Marius
Kamandulis, Sigitas
Lanner, Johanna T.
Yeo, Gene W.
Ruas, Jorge L.
author_sort Correia, Jorge C.
collection PubMed
description Muscular atrophy is a mortality risk factor that happens with disuse, chronic disease, and aging. Recovery from atrophy requires changes in several cell types including muscle fibers, and satellite and immune cells. Here we show that Zfp697/ZNF697 is a damage-induced regulator of muscle regeneration, during which its expression is transiently elevated. Conversely, sustained Zfp697 expression in mouse muscle leads to a gene expression signature of chemokine secretion, immune cell recruitment, and extracellular matrix remodeling. Myofiber-specific Zfp697 ablation hinders the inflammatory and regenerative response to muscle injury, compromising functional recovery. We uncover Zfp697 as an essential interferon gamma mediator in muscle cells, interacting primarily with ncRNAs such as the pro-regenerative miR-206. In sum, we identify Zfp697 as an integrator of cell-cell communication necessary for tissue regeneration.
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spelling pubmed-103126352023-07-01 Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and regeneration Correia, Jorge C. Jannig, Paulo R. Gosztyla, Maya L. Cervenka, Igor Ducommun, Serge Præstholm, Stine M. Dumont, Kyle Liu, Zhengye Liang, Qishan Edsgärd, Daniel Emanuelsson, Olof Gregorevic, Paul Westerblad, Håkan Venckunas, Tomas Brazaitis, Marius Kamandulis, Sigitas Lanner, Johanna T. Yeo, Gene W. Ruas, Jorge L. bioRxiv Article Muscular atrophy is a mortality risk factor that happens with disuse, chronic disease, and aging. Recovery from atrophy requires changes in several cell types including muscle fibers, and satellite and immune cells. Here we show that Zfp697/ZNF697 is a damage-induced regulator of muscle regeneration, during which its expression is transiently elevated. Conversely, sustained Zfp697 expression in mouse muscle leads to a gene expression signature of chemokine secretion, immune cell recruitment, and extracellular matrix remodeling. Myofiber-specific Zfp697 ablation hinders the inflammatory and regenerative response to muscle injury, compromising functional recovery. We uncover Zfp697 as an essential interferon gamma mediator in muscle cells, interacting primarily with ncRNAs such as the pro-regenerative miR-206. In sum, we identify Zfp697 as an integrator of cell-cell communication necessary for tissue regeneration. Cold Spring Harbor Laboratory 2023-06-13 /pmc/articles/PMC10312635/ /pubmed/37398033 http://dx.doi.org/10.1101/2023.06.12.544338 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Correia, Jorge C.
Jannig, Paulo R.
Gosztyla, Maya L.
Cervenka, Igor
Ducommun, Serge
Præstholm, Stine M.
Dumont, Kyle
Liu, Zhengye
Liang, Qishan
Edsgärd, Daniel
Emanuelsson, Olof
Gregorevic, Paul
Westerblad, Håkan
Venckunas, Tomas
Brazaitis, Marius
Kamandulis, Sigitas
Lanner, Johanna T.
Yeo, Gene W.
Ruas, Jorge L.
Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and regeneration
title Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and regeneration
title_full Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and regeneration
title_fullStr Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and regeneration
title_full_unstemmed Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and regeneration
title_short Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and regeneration
title_sort zfp697 is an rna-binding protein that regulates skeletal muscle inflammation and regeneration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312635/
https://www.ncbi.nlm.nih.gov/pubmed/37398033
http://dx.doi.org/10.1101/2023.06.12.544338
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