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AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor

Protein-protein interactions (PPIs) offer great opportunities to expand the druggable proteome and therapeutically tackle various diseases, but remain challenging targets for drug discovery. Here, we provide a comprehensive pipeline that combines experimental and computational tools to identify and...

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Detalles Bibliográficos
Autores principales:	Trepte, Philipp, Secker, Christopher, Kostova, Simona, Maseko, Sibusiso B., Choi, Soon Gang, Blavier, Jeremy, Minia, Igor, Ramos, Eduardo Silva, Cassonnet, Patricia, Golusik, Sabrina, Zenkner, Martina, Beetz, Stephanie, Liebich, Mara J., Scharek, Nadine, Schütz, Anja, Sperling, Marcel, Lisurek, Michael, Wang, Yang, Spirohn, Kerstin, Hao, Tong, Calderwood, Michael A., Hill, David E., Landthaler, Markus, Olivet, Julien, Twizere, Jean-Claude, Vidal, Marc, Wanker, Erich E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312674/ https://www.ncbi.nlm.nih.gov/pubmed/37398436 http://dx.doi.org/10.1101/2023.06.14.544560

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