Live-cell invasive phenotyping uncovers the ALK2/BMP6 iron homeostasis pathway as a therapeutic vulnerability in LKB1-mutant lung cancer

The acquisition of invasive properties is a prerequisite for tumor progression and metastasis. Molecular subtypes of KRAS-driven lung cancer exhibit distinct modes of invasion that likely contribute to unique growth properties and therapeutic susceptibilities. Despite this, pre-clinical discovery st...

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Detalles Bibliográficos
Autores principales: Koo, Junghui, Seong, Chang-Soo, Parker, Rebecca E., Dwivedi, Bhakti, Arthur, Robert A., Dinasarapu, Ashok Reddy, Johnston, H. Richard, Claussen, Henry, Tucker-Burden, Carol, Ramalingam, Suresh S., Fu, Haian, Zhou, Wei, Marcus, Adam I., Gilbert-Ross, Melissa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312689/
https://www.ncbi.nlm.nih.gov/pubmed/37398244
http://dx.doi.org/10.1101/2023.06.14.544941

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