Polygenic adaptation to overnutrition reveals a role for cholinergic signaling in longevity

Overnutrition by high-sugar (HS) feeding reduces both the lifespan and healthspan across taxa. Pressuring organisms to adapt to overnutrition can highlight genes and pathways important for the healthspan in stressful environments. We used an experimental evolution approach to adapt four replicate, o...

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Detalles Bibliográficos
Autores principales: Rundell, Thomas B, Brunelli, Melina, Alvi, Azva, Safian, Gabrielle, Capobianco, Christina, Tu, Wangshu, Subedi, Sanjeena, Fiumera, Anthony, Musselman, Laura Palanker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312690/
https://www.ncbi.nlm.nih.gov/pubmed/37398379
http://dx.doi.org/10.1101/2023.06.14.544888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312690/
https://www.ncbi.nlm.nih.gov/pubmed/37398379
http://dx.doi.org/10.1101/2023.06.14.544888

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