Small Interactor of PKD2 (SIP), a novel PKD2-related single-pass transmembrane protein, is required for proteolytic processing and ciliary import of Chlamydomonas PKD2

In Chlamydomonas cilia, the ciliopathy-relevant TRP channel PKD2 is spatially compartmentalized into a distal region, in which PKD2 binds the axoneme and extracellular mastigonemes, and a smaller proximal region, in which PKD2 is more mobile and lacks mastigonemes. Here, we show that the two PKD2 re...

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Detalles Bibliográficos
Autores principales: Das, Poulomi, Mekonnen, Betlehem, Alkhofash, Rama, Ingle, Abha, Workman, E. Blair, Feather, Alec, Liu, Peiwei, Lechtreck, Karl F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312728/
https://www.ncbi.nlm.nih.gov/pubmed/37398320
http://dx.doi.org/10.1101/2023.06.13.544839

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