Fusion crystallization reveals the behavior of both the 1TEL crystallization chaperone and the TNK1 UBA domain

Human thirty-eight-negative kinase-1 (TNK1) is implicated in cancer progression. The TNK1-UBA domain binds polyubiquitin and plays a regulatory role in TNK1 activity and stability. Sequence analysis suggests an unusual architecture for the TNK1 UBA domain, but an experimentally-validated molecular s...

Descripción completa

Detalles Bibliográficos
Autores principales: Nawarathnage, Supeshala, Tseng, Yi Jie, Soleimani, Sara, Smith, Tobin, Romo, Maria J Pedroza, Abiodun, Wisdom Oshireku, Egbert, Christina M., Madhusanka, Deshan, Bunn, Derick, Woods, Bridger, Tsubaki, Evan, Stewart, Cameron, Brown, Seth, Doukov, Tzanko, Andersen, Joshua L., Moody, James D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312729/
https://www.ncbi.nlm.nih.gov/pubmed/37398013
http://dx.doi.org/10.1101/2023.06.14.544429

Ejemplares similares

Ejemplares similares