MNK inhibitor eFT508 (Tomivosertib) suppresses ectopic activity in human dorsal root ganglion neurons from dermatomes with radicular neuropathic pain

Spontaneous activity in dorsal root ganglion (DRG) neurons is a key driver of neuropathic pain in preclinical models and in patients suffering from this largely untreated disease. While many intracellular signaling mechanisms have been examined in preclinical models that drive this spontaneous activ...

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Detalles Bibliográficos
Autores principales: Li, Yan, Uhelski, Megan L., North, Robert Y., Mwirigi, Juliet M., Tatsui, Claudio E., Cata, Juan P., Corrales, German, Price, Theodore J., Dougherty, Patrick M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312735/
https://www.ncbi.nlm.nih.gov/pubmed/37398249
http://dx.doi.org/10.1101/2023.06.13.544811

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