CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis

A hallmark of age-associated neurodegenerative diseases is the aggregation of proteins. Aggregation of the protein tau defines tauopathies, which include Alzheimer’s disease and frontotemporal dementia. Specific neuronal subtypes are selectively vulnerable to the accumulation of tau aggregates, and...

Descripción completa

Detalles Bibliográficos
Autores principales: Samelson, Avi J., Ariqat, Nabeela, McKetney, Justin, Rohanitazangi, Gita, Bravo, Celeste Parra, Goodness, Darrin, Tian, Ruilin, Grosjean, Parker, Abskharon, Romany, Eisenberg, David, Kanaan, Nicholas M., Gan, Li, Condello, Carlo, Swaney, Danielle L., Kampmann, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312804/
https://www.ncbi.nlm.nih.gov/pubmed/37398204
http://dx.doi.org/10.1101/2023.06.16.545386

Ejemplares similares

Ejemplares similares