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Fibration symmetries and cluster synchronization in the Caenorhabditis elegans connectome

Capturing how the Caenorhabditis elegans connectome structure gives rise to its neuron functionality remains unclear. It is through fiber symmetries found in its neuronal connectivity that synchronization of a group of neurons can be determined. To understand these we investigate graph symmetries an...

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Autores principales: Avila, Bryant, Serafino, Matteo, Augusto, Pedro, Zimmer, Manuel, Makse, Hernán A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cornell University 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312817/
https://www.ncbi.nlm.nih.gov/pubmed/37396607
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author Avila, Bryant
Serafino, Matteo
Augusto, Pedro
Zimmer, Manuel
Makse, Hernán A.
author_facet Avila, Bryant
Serafino, Matteo
Augusto, Pedro
Zimmer, Manuel
Makse, Hernán A.
author_sort Avila, Bryant
collection PubMed
description Capturing how the Caenorhabditis elegans connectome structure gives rise to its neuron functionality remains unclear. It is through fiber symmetries found in its neuronal connectivity that synchronization of a group of neurons can be determined. To understand these we investigate graph symmetries and search for such in the symmetrized versions of the forward and backward locomotive sub-networks of the Caenorhabditi elegans worm neuron network. The use of ordinarily differential equations simulations admissible to these graphs are used to validate the predictions of these fiber symmetries and are compared to the more restrictive orbit symmetries. Additionally fibration symmetries are used to decompose these graphs into their fundamental building blocks which reveal units formed by nested loops or multilayered fibers. It is found that fiber symmetries of the connectome can accurately predict neuronal synchronization even under not idealized connectivity as long as the dynamics are within stable regimes of simulations.
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spelling pubmed-103128172023-07-01 Fibration symmetries and cluster synchronization in the Caenorhabditis elegans connectome Avila, Bryant Serafino, Matteo Augusto, Pedro Zimmer, Manuel Makse, Hernán A. ArXiv Article Capturing how the Caenorhabditis elegans connectome structure gives rise to its neuron functionality remains unclear. It is through fiber symmetries found in its neuronal connectivity that synchronization of a group of neurons can be determined. To understand these we investigate graph symmetries and search for such in the symmetrized versions of the forward and backward locomotive sub-networks of the Caenorhabditi elegans worm neuron network. The use of ordinarily differential equations simulations admissible to these graphs are used to validate the predictions of these fiber symmetries and are compared to the more restrictive orbit symmetries. Additionally fibration symmetries are used to decompose these graphs into their fundamental building blocks which reveal units formed by nested loops or multilayered fibers. It is found that fiber symmetries of the connectome can accurately predict neuronal synchronization even under not idealized connectivity as long as the dynamics are within stable regimes of simulations. Cornell University 2023-05-30 /pmc/articles/PMC10312817/ /pubmed/37396607 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Article
Avila, Bryant
Serafino, Matteo
Augusto, Pedro
Zimmer, Manuel
Makse, Hernán A.
Fibration symmetries and cluster synchronization in the Caenorhabditis elegans connectome
title Fibration symmetries and cluster synchronization in the Caenorhabditis elegans connectome
title_full Fibration symmetries and cluster synchronization in the Caenorhabditis elegans connectome
title_fullStr Fibration symmetries and cluster synchronization in the Caenorhabditis elegans connectome
title_full_unstemmed Fibration symmetries and cluster synchronization in the Caenorhabditis elegans connectome
title_short Fibration symmetries and cluster synchronization in the Caenorhabditis elegans connectome
title_sort fibration symmetries and cluster synchronization in the caenorhabditis elegans connectome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312817/
https://www.ncbi.nlm.nih.gov/pubmed/37396607
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