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Apolipoprotein E moderates the association between Non-APOE Polygenic Risk Score for Alzheimer’s Disease and Aging on Preclinical Cognitive Function

INTRODUCTION: Variation in preclinical cognitive decline suggests additional genetic factors related to Alzheimer’s disease (e.g., a non-APOE polygenic risk scores [PRS]) may interact with the APOE ε4 allele to influence cognitive decline. METHODS: We tested the PRS×APOE ε4×age interaction on precli...

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Detalles Bibliográficos
Autores principales:	Xu, Yuexuan, Sun, Zhongxuan, Jonaitis, Erin, Deming, Yuetiva, Lu, Qiongshi, Johnson, Sterling C., Engelman, Corinne D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312823/ https://www.ncbi.nlm.nih.gov/pubmed/37398140 http://dx.doi.org/10.1101/2023.06.09.23291215

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