Abnormal lymphatic S1P signaling aggravates lymphatic dysfunction and tissue inflammation

BACKGROUND: Lymphedema is a global health problem with no effective drug treatment. Enhanced T cell immunity and abnormal lymphatic endothelial cell (LEC) signaling are promising therapeutic targets for this condition. Sphingosine-1-phosphate (S1P) mediates a key signaling pathway required for norma...

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Detalles Bibliográficos
Autores principales: Kim, Dongeon, Tian, Wen, Wu, Timothy Ting-Hsuan, Xiang, Menglan, Vinh, Ryan, Chang, Jason, Gu, Shenbiao, Lee, Seunghee, Zhu, Yu, Guan, Torrey, Schneider, Emilie Claire, Bao, Evan, Dixon, J. Brandon, Kao, Peter, Pan, Junliang, Rockson, Stanley G., Jiang, Xinguo, Nicolls, Mark Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312855/
https://www.ncbi.nlm.nih.gov/pubmed/37398237
http://dx.doi.org/10.1101/2023.06.08.23291175

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