FET fusion oncoproteins disrupt physiologic DNA repair networks and induce ATR synthetic lethality in cancer

The genetic principle of synthetic lethality is clinically validated in cancers with loss of specific DNA damage response (DDR) pathway genes (i.e. BRCA1/2 tumor suppressor mutations). The broader question of whether and how oncogenes create tumor-specific vulnerabilities within DDR networks remains...

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Detalles Bibliográficos
Autores principales: Menon, Shruti, Breese, Marcus R., Lin, Yone Phar, Allegakoen, Hannah, Perati, Shruthi, Heslin, Ann, Horlbeck, Max A., Weissman, Jonathan, Sweet-Cordero, E. Alejandro, Bivona, Trever G., Tulpule, Asmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312925/
https://www.ncbi.nlm.nih.gov/pubmed/37398210
http://dx.doi.org/10.21203/rs.3.rs-2869150/v1

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