Malignant A-to-I RNA editing by ADAR1 drives T-cell acute lymphoblastic leukemia relapse via attenuating dsRNA sensing

Leukemia initiating cells (LICs) are regarded as the origin of leukemia relapse and therapeutic resistance. Identifying direct stemness determinants that fuel LIC self-renewal is critical for developing targeted approaches to eliminate LICs and prevent relapse. Here, we show that the RNA editing enz...

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Detalles Bibliográficos
Autores principales: Rivera, Maria, Zhang, Haoran, Pham, Jessica, Isquith, Jane, Zhou, Qingchen Jenny, Sasik, Roman, Mark, Adam, Ma, Wenxue, Holm, Frida, Fisch, Kathleen M, Kuo, Dennis John, Jamieson, Catriona, Jiang, Qingfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312963/
https://www.ncbi.nlm.nih.gov/pubmed/37398458
http://dx.doi.org/10.21203/rs.3.rs-2444524/v2

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