Anticancer properties of sulforaphane: current insights at the molecular level

Sulforaphane (SFN) is an isothiocyanate with multiple biomedical applications. Sulforaphane can be extracted from the plants of the genus Brassica. However, broccoli sprouts are the chief source of sulforaphane and are 20 to 50 times richer than mature broccoli as they contain 1,153 mg/100 g. SFN is...

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Detalles Bibliográficos
Autores principales: Asif Ali, Muhammad, Khan, Noohela, Kaleem, Nabeeha, Ahmad, Waqas, Alharethi, Salem Hussain, Alharbi, Bandar, Alhassan, Hassan H., Al-Enazi, Maher M., Razis, Ahmad Faizal Abdull, Modu, Babagana, Calina, Daniela, Sharifi-Rad, Javad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313060/
https://www.ncbi.nlm.nih.gov/pubmed/37397365
http://dx.doi.org/10.3389/fonc.2023.1168321
Descripción
Sumario:Sulforaphane (SFN) is an isothiocyanate with multiple biomedical applications. Sulforaphane can be extracted from the plants of the genus Brassica. However, broccoli sprouts are the chief source of sulforaphane and are 20 to 50 times richer than mature broccoli as they contain 1,153 mg/100 g. SFN is a secondary metabolite that is produced as a result of the hydrolysis of glucoraphanin (a glucosinolate) by the enzyme myrosinase. This review paper aims to summarize and understand the mechanisms behind the anticancer potential of sulforaphane. The data was collected by searching PubMed/MedLine, Scopus, Web of Science, and Google Scholar. This paper concludes that sulforaphane provides cancer protection through the alteration of various epigenetic and non-epigenetic pathways. It is a potent anticancer phytochemical that is safe to consume with minimal side effects. However, there is still a need for further research regarding SFN and the development of a standard dose.

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