Monocytic MDSCs exhibit superior immune suppression via adenosine and depletion of adenosine improves efficacy of immunotherapy

Immune checkpoint inhibitor (ICI) therapy is effective against many cancers for a subset of patients; a large percentage of patients remain unresponsive to this therapy. One contributing factor to ICI resistance is accumulation of monocytic myeloid-derived suppressor cells (M-MDSCs), a subset of inn...

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Detalles Bibliográficos
Autores principales: Sarkar, Omar S., Donninger, Howard, Al Rayyan, Numan, Chew, Lewis C., Stamp, Bryce, Zhang, Xiang, Whitt, Aaron, Li, Chi, Hall, Melissa, Mitchell, Robert A., Zippelius, Alfred, Eaton, John, Chesney, Jason A., Yaddanapudi, Kavitha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313166/
https://www.ncbi.nlm.nih.gov/pubmed/37390211
http://dx.doi.org/10.1126/sciadv.adg3736

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