A localized hydrogel-mediated chemotherapy causes immunogenic cell death via activation of ceramide-mediated unfolded protein response

Treatment of triple-negative breast cancer (TNBC) is challenging because of its “COLD” tumor immunosuppressive microenvironment (TIME). Here, we present a hydrogel-mediated localized delivery of a combination of docetaxel (DTX) and carboplatin (CPT) (called DTX-CPT-Gel therapy) that ensured enhanced...

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Detalles Bibliográficos
Autores principales: Kar, Animesh, Jain, Dolly, Kumar, Sandeep, Rajput, Kajal, Pal, Sanjay, Rana, Kajal, Kar, Raunak, Jha, Somesh K., Medatwal, Nihal, Yavvari, Prabhu Srinivas, Pandey, Nishant, Mehta, Devashish, Sharma, Harsh, Bhattacharya, Debanjan, Pradhan, Manas K., Sharma, Ravi Datta, Srivastava, Aasheesh, Agrawal, Usha, Mukhopadhyay, Arnab, Sengupta, Sagar, Patil, Veena S., Bajaj, Avinash, Dasgupta, Ujjaini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313169/
https://www.ncbi.nlm.nih.gov/pubmed/37390205
http://dx.doi.org/10.1126/sciadv.adf2746

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