Impact of an SLC30A8 loss-of-function variant on the pancreatic distribution of zinc and manganese: laser ablation-ICP-MS and positron emission tomography studies in mice

INTRODUCTION: Common variants in the SLC30A8 gene, encoding the secretory granule zinc transporter ZnT8 (expressed largely in pancreatic islet alpha and beta cells), are associated with altered risk of type 2 diabetes. Unexpectedly, rare loss-of-function (LoF) variants in the gene, described in hete...

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Detalles Bibliográficos
Autores principales: Firth, George, Georgiadou, Eleni, Griffiths, Alexander, Amrahli, Maral, Kim, Jana, Yu, Zilin, Hu, Ming, Stewart, Theodora J., Leclerc, Isabelle, Okamoto, Haruka, Gomez, Daniel, Blower, Philip J., Rutter, Guy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313231/
https://www.ncbi.nlm.nih.gov/pubmed/37396167
http://dx.doi.org/10.3389/fendo.2023.1171933

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