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Association between pregnant women with rheumatoid arthritis and preeclampsia: A systematic review and meta-analysis
To examine the association between pregnant women with rheumatoid arthritis (RA) and the risk of preeclampsia. METHODS: This study was registered on the International Prospective Register of Systematic Reviews (PROSPERO) under the number CRD42022361571. The primary outcome was preeclampsia. Two eval...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313298/ https://www.ncbi.nlm.nih.gov/pubmed/37390281 http://dx.doi.org/10.1097/MD.0000000000034131 |
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author | Tian, Lv Zhang, Zhiyuan Mao, Yuting Zong, Minru |
author_facet | Tian, Lv Zhang, Zhiyuan Mao, Yuting Zong, Minru |
author_sort | Tian, Lv |
collection | PubMed |
description | To examine the association between pregnant women with rheumatoid arthritis (RA) and the risk of preeclampsia. METHODS: This study was registered on the International Prospective Register of Systematic Reviews (PROSPERO) under the number CRD42022361571. The primary outcome was preeclampsia. Two evaluators independently reviewed the included studies, assessed their risk of bias, and extracted the data. Unadjusted and adjusted ratios with 95% confidence intervals and 95% prediction intervals were calculated. Heterogeneity was quantified using the І(2) statistic, where І(2) ≥ 50% indicated the presence of significant heterogeneity. Subgroup and sensitivity analyses were performed to test the robustness of the overall findings. RESULTS: A total of 8 studies, including 10,951,184 pregnant women, of whom 13,333 were diagnosed with RA, met the inclusion criteria. Meta-analysis revealed that pregnant women with RA were significantly more likely to develop preeclampsia than those without RA (pooled odds ratio, 1.66; 95% confidence interval, 1.52–1.80; P < .001; І(2) < .001). CONCLUSION: RA during pregnancy is associated with higher odds of preeclampsia. |
format | Online Article Text |
id | pubmed-10313298 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-103132982023-07-01 Association between pregnant women with rheumatoid arthritis and preeclampsia: A systematic review and meta-analysis Tian, Lv Zhang, Zhiyuan Mao, Yuting Zong, Minru Medicine (Baltimore) 6900 To examine the association between pregnant women with rheumatoid arthritis (RA) and the risk of preeclampsia. METHODS: This study was registered on the International Prospective Register of Systematic Reviews (PROSPERO) under the number CRD42022361571. The primary outcome was preeclampsia. Two evaluators independently reviewed the included studies, assessed their risk of bias, and extracted the data. Unadjusted and adjusted ratios with 95% confidence intervals and 95% prediction intervals were calculated. Heterogeneity was quantified using the І(2) statistic, where І(2) ≥ 50% indicated the presence of significant heterogeneity. Subgroup and sensitivity analyses were performed to test the robustness of the overall findings. RESULTS: A total of 8 studies, including 10,951,184 pregnant women, of whom 13,333 were diagnosed with RA, met the inclusion criteria. Meta-analysis revealed that pregnant women with RA were significantly more likely to develop preeclampsia than those without RA (pooled odds ratio, 1.66; 95% confidence interval, 1.52–1.80; P < .001; І(2) < .001). CONCLUSION: RA during pregnancy is associated with higher odds of preeclampsia. Lippincott Williams & Wilkins 2023-06-30 /pmc/articles/PMC10313298/ /pubmed/37390281 http://dx.doi.org/10.1097/MD.0000000000034131 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | 6900 Tian, Lv Zhang, Zhiyuan Mao, Yuting Zong, Minru Association between pregnant women with rheumatoid arthritis and preeclampsia: A systematic review and meta-analysis |
title | Association between pregnant women with rheumatoid arthritis and preeclampsia: A systematic review and meta-analysis |
title_full | Association between pregnant women with rheumatoid arthritis and preeclampsia: A systematic review and meta-analysis |
title_fullStr | Association between pregnant women with rheumatoid arthritis and preeclampsia: A systematic review and meta-analysis |
title_full_unstemmed | Association between pregnant women with rheumatoid arthritis and preeclampsia: A systematic review and meta-analysis |
title_short | Association between pregnant women with rheumatoid arthritis and preeclampsia: A systematic review and meta-analysis |
title_sort | association between pregnant women with rheumatoid arthritis and preeclampsia: a systematic review and meta-analysis |
topic | 6900 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313298/ https://www.ncbi.nlm.nih.gov/pubmed/37390281 http://dx.doi.org/10.1097/MD.0000000000034131 |
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