Constitutive activation and oncogenicity are mediated by loss of helical structure at the cytosolic boundary of thrombopoietin receptor mutant dimers

Dimerization of the thrombopoietin receptor (TpoR) is necessary for receptor activation and downstream signaling through activated Janus kinase 2. We have shown previously that different orientations of the transmembrane (TM) helices within a receptor dimer can lead to different signaling outputs. H...

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Detalles Bibliográficos
Autores principales: Defour, Jean-Philippe, Leroy, Emilie, Dass, Sharmila, Balligand, Thomas, Levy, Gabriel, Brett, Ian C, Papadopoulos, Nicolas, Mouton, Céline, Genet, Lidvine, Pecquet, Christian, Staerk, Judith, Smith, Steven O, Constantinescu, Stefan N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313314/
https://www.ncbi.nlm.nih.gov/pubmed/37338955
http://dx.doi.org/10.7554/eLife.81521

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313314/
https://www.ncbi.nlm.nih.gov/pubmed/37338955
http://dx.doi.org/10.7554/eLife.81521

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