Metastatic Adrenocortical Carcinoma With Chromothripsis: A Case Report and Literature Review

Metastatic adrenocortical carcinoma (ACC) often has a poor outcome, with a five-year survival of less than 25%. We report a rare case of metastatic ACC with a myxoid variant with chromothripsis. We review the histologic variants of ACC, including myxoid type, molecular drivers, and current and inves...

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Detalles Bibliográficos
Autores principales: Seong, Gyuhee, Wu, Alexander, Kim, Charles, Pathak, Nirmal, Yakut, Elif, Li, Zhonghua, Chiu, Edwin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Endocrinology/Diabetes/Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313339/
https://www.ncbi.nlm.nih.gov/pubmed/37397681
http://dx.doi.org/10.7759/cureus.41218
Descripción
Sumario:Metastatic adrenocortical carcinoma (ACC) often has a poor outcome, with a five-year survival of less than 25%. We report a rare case of metastatic ACC with a myxoid variant with chromothripsis. We review the histologic variants of ACC, including myxoid type, molecular drivers, and current and investigational therapies for adrenocortical carcinoma. We also discuss the mechanism of chromothripsis, chromothripsis in ACC tumorigenesis, and propose potential therapies targeting chromothripsis.

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