Metastatic Adrenocortical Carcinoma With Chromothripsis: A Case Report and Literature Review

Metastatic adrenocortical carcinoma (ACC) often has a poor outcome, with a five-year survival of less than 25%. We report a rare case of metastatic ACC with a myxoid variant with chromothripsis. We review the histologic variants of ACC, including myxoid type, molecular drivers, and current and inves...

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Detalles Bibliográficos
Autores principales: Seong, Gyuhee, Wu, Alexander, Kim, Charles, Pathak, Nirmal, Yakut, Elif, Li, Zhonghua, Chiu, Edwin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Endocrinology/Diabetes/Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313339/
https://www.ncbi.nlm.nih.gov/pubmed/37397681
http://dx.doi.org/10.7759/cureus.41218
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author Seong, Gyuhee
Wu, Alexander
Kim, Charles
Pathak, Nirmal
Yakut, Elif
Li, Zhonghua
Chiu, Edwin
author_facet Seong, Gyuhee
Wu, Alexander
Kim, Charles
Pathak, Nirmal
Yakut, Elif
Li, Zhonghua
Chiu, Edwin
author_sort Seong, Gyuhee
collection PubMed
description Metastatic adrenocortical carcinoma (ACC) often has a poor outcome, with a five-year survival of less than 25%. We report a rare case of metastatic ACC with a myxoid variant with chromothripsis. We review the histologic variants of ACC, including myxoid type, molecular drivers, and current and investigational therapies for adrenocortical carcinoma. We also discuss the mechanism of chromothripsis, chromothripsis in ACC tumorigenesis, and propose potential therapies targeting chromothripsis.
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spelling pubmed-103133392023-07-01 Metastatic Adrenocortical Carcinoma With Chromothripsis: A Case Report and Literature Review Seong, Gyuhee Wu, Alexander Kim, Charles Pathak, Nirmal Yakut, Elif Li, Zhonghua Chiu, Edwin Cureus Endocrinology/Diabetes/Metabolism Metastatic adrenocortical carcinoma (ACC) often has a poor outcome, with a five-year survival of less than 25%. We report a rare case of metastatic ACC with a myxoid variant with chromothripsis. We review the histologic variants of ACC, including myxoid type, molecular drivers, and current and investigational therapies for adrenocortical carcinoma. We also discuss the mechanism of chromothripsis, chromothripsis in ACC tumorigenesis, and propose potential therapies targeting chromothripsis. Cureus 2023-06-30 /pmc/articles/PMC10313339/ /pubmed/37397681 http://dx.doi.org/10.7759/cureus.41218 Text en Copyright © 2023, Seong et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Seong, Gyuhee
Wu, Alexander
Kim, Charles
Pathak, Nirmal
Yakut, Elif
Li, Zhonghua
Chiu, Edwin
Metastatic Adrenocortical Carcinoma With Chromothripsis: A Case Report and Literature Review
title Metastatic Adrenocortical Carcinoma With Chromothripsis: A Case Report and Literature Review
title_full Metastatic Adrenocortical Carcinoma With Chromothripsis: A Case Report and Literature Review
title_fullStr Metastatic Adrenocortical Carcinoma With Chromothripsis: A Case Report and Literature Review
title_full_unstemmed Metastatic Adrenocortical Carcinoma With Chromothripsis: A Case Report and Literature Review
title_short Metastatic Adrenocortical Carcinoma With Chromothripsis: A Case Report and Literature Review
title_sort metastatic adrenocortical carcinoma with chromothripsis: a case report and literature review
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313339/
https://www.ncbi.nlm.nih.gov/pubmed/37397681
http://dx.doi.org/10.7759/cureus.41218
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