Therapeutic targeting of metabolic vulnerabilities in cancers with MLL3/4-COMPASS epigenetic regulator mutations

Epigenetic status–altering mutations in chromatin-modifying enzymes are a feature of human diseases, including many cancers. However, the functional outcomes and cellular dependencies arising from these mutations remain unresolved. In this study, we investigated cellular dependencies, or vulnerabili...

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Detalles Bibliográficos
Autores principales: Zhao, Zibo, Cao, Kaixiang, Watanabe, Jun, Philips, Cassandra N., Zeidner, Jacob M., Ishi, Yukitomo, Wang, Qixuan, Gold, Sarah R., Junkins, Katherine, Bartom, Elizabeth T., Yue, Feng, Chandel, Navdeep S., Hashizume, Rintaro, Ben-Sahra, Issam, Shilatifard, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313365/
https://www.ncbi.nlm.nih.gov/pubmed/37252797
http://dx.doi.org/10.1172/JCI169993

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