Atrx deletion impairs CGAS/STING signaling and increases sarcoma response to radiation and oncolytic herpesvirus

ATRX is one of the most frequently altered genes in solid tumors, and mutation is especially frequent in soft tissue sarcomas. However, the role of ATRX in tumor development and response to cancer therapies remains poorly understood. Here, we developed a primary mouse model of soft tissue sarcoma an...

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Detalles Bibliográficos
Autores principales: Floyd, Warren, Pierpoint, Matthew, Su, Chang, Patel, Rutulkumar, Luo, Lixia, Deland, Katherine, Wisdom, Amy J., Zhu, Daniel, Ma, Yan, DeWitt, Suzanne Bartholf, Williams, Nerissa T., Lazarides, Alexander L., Somarelli, Jason A., Corcoran, David L., Eward, William C., Cardona, Diana M., Kirsch, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313374/
https://www.ncbi.nlm.nih.gov/pubmed/37200088
http://dx.doi.org/10.1172/JCI149310

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