T-BET and EOMES sustain mature human NK cell identity and antitumor function

Since the T-box transcription factors (TFs) T-BET and EOMES are necessary for initiation of NK cell development, their ongoing requirement for mature NK cell homeostasis, function, and molecular programming remains unclear. To address this, T-BET and EOMES were deleted in unexpanded primary human NK...

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Detalles Bibliográficos
Autores principales: Wong, Pamela, Foltz, Jennifer A., Chang, Lily, Neal, Carly C., Yao, Tony, Cubitt, Celia C., Tran, Jennifer, Kersting-Schadek, Samantha, Palakurty, Sathvik, Jaeger, Natalia, Russler-Germain, David A., Marin, Nancy D., Gang, Margery, Wagner, Julia A., Zhou, Alice Y., Jacobs, Miriam T., Foster, Mark, Schappe, Timothy, Marsala, Lynne, McClain, Ethan, Pence, Patrick, Becker-Hapak, Michelle, Fisk, Bryan, Petti, Allegra A., Griffith, Obi L., Griffith, Malachi, Berrien-Elliott, Melissa M., Fehniger, Todd A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313375/
https://www.ncbi.nlm.nih.gov/pubmed/37279078
http://dx.doi.org/10.1172/JCI162530

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