SELENOP modifies sporadic colorectal carcinogenesis and WNT signaling activity through LRP5/6 interactions

Although selenium deficiency correlates with colorectal cancer (CRC) risk, the roles of the selenium-rich antioxidant selenoprotein P (SELENOP) in CRC remain unclear. In this study, we defined SELENOP’s contributions to sporadic CRC. In human single-cell cRNA-Seq (scRNA-Seq) data sets, we discovered...

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Detalles Bibliográficos
Autores principales: Pilat, Jennifer M., Brown, Rachel E., Chen, Zhengyi, Berle, Nathaniel J., Othon, Adrian P., Washington, M. Kay, Anant, Shruti A., Kurokawa, Suguru, Ng, Victoria H., Thompson, Joshua J., Jacobse, Justin, Goettel, Jeremy A., Lee, Ethan, Choksi, Yash A., Lau, Ken S., Short, Sarah P., Williams, Christopher S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313376/
https://www.ncbi.nlm.nih.gov/pubmed/37166989
http://dx.doi.org/10.1172/JCI165988

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