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Circulating miR-183-5p levels are positively associated with the presence and severity of coronary artery disease
BACKGROUND: Serum miR-183-5p levels are associated with carotid atherosclerosis, while less is known about the relationship between circulating miR-183-5p levels and stable coronary artery disease (CAD). METHODS: In this cross-sectional study, consecutive patients with chest pain who underwent coron...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313402/ https://www.ncbi.nlm.nih.gov/pubmed/37396583 http://dx.doi.org/10.3389/fcvm.2023.1196348 |
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author | Lv, Dong Guo, Yanfu Zhang, Li Li, Xia Li, Guangping |
author_facet | Lv, Dong Guo, Yanfu Zhang, Li Li, Xia Li, Guangping |
author_sort | Lv, Dong |
collection | PubMed |
description | BACKGROUND: Serum miR-183-5p levels are associated with carotid atherosclerosis, while less is known about the relationship between circulating miR-183-5p levels and stable coronary artery disease (CAD). METHODS: In this cross-sectional study, consecutive patients with chest pain who underwent coronary angiograms from January 2022 to March 2022 at our center were enrolled. Those presenting acute coronary syndrome or had a prior CAD were excluded. Clinical presentations, laboratory parameters, and angiographic findings were collected. Serum miR-183-5p levels were measured using quantitative real-time polymerase chain reaction. CAD severity was displayed as the number of diseased vessels and further evaluated by the Gensini score system. RESULTS: Overall, 135 patients (median age, 62.0 years; male, 52.6%) were included in the present study. Stable CAD was identified in 85.2% of the study population, with 45.9% having 1-vessel disease, 21.5% having 2-vessel disease, and 17.8% having 3-vessel or left main disease. Serum miR-183-5p levels were significantly increased in CAD patients with different severities than non-CAD patients (all adjusted p < 0.05). Serum miR-183-5p levels increased as tertiles of the Gensini score progressed (all adjusted p < 0.05). Importantly, serum miR-183-5p levels could predict the presence of CAD and 3-vessel or left main disease in the receiver operating characteristic curve analysis (both p < 0.01), and also in multivariate analysis adjusting for age, sex, body mass index, diabetes, hypersensitive-C-reactive protein (both p < 0.05). CONCLUSION: Serum miR-183-5p levels are independently and positively correlated with CAD presence and severity. |
format | Online Article Text |
id | pubmed-10313402 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103134022023-07-01 Circulating miR-183-5p levels are positively associated with the presence and severity of coronary artery disease Lv, Dong Guo, Yanfu Zhang, Li Li, Xia Li, Guangping Front Cardiovasc Med Cardiovascular Medicine BACKGROUND: Serum miR-183-5p levels are associated with carotid atherosclerosis, while less is known about the relationship between circulating miR-183-5p levels and stable coronary artery disease (CAD). METHODS: In this cross-sectional study, consecutive patients with chest pain who underwent coronary angiograms from January 2022 to March 2022 at our center were enrolled. Those presenting acute coronary syndrome or had a prior CAD were excluded. Clinical presentations, laboratory parameters, and angiographic findings were collected. Serum miR-183-5p levels were measured using quantitative real-time polymerase chain reaction. CAD severity was displayed as the number of diseased vessels and further evaluated by the Gensini score system. RESULTS: Overall, 135 patients (median age, 62.0 years; male, 52.6%) were included in the present study. Stable CAD was identified in 85.2% of the study population, with 45.9% having 1-vessel disease, 21.5% having 2-vessel disease, and 17.8% having 3-vessel or left main disease. Serum miR-183-5p levels were significantly increased in CAD patients with different severities than non-CAD patients (all adjusted p < 0.05). Serum miR-183-5p levels increased as tertiles of the Gensini score progressed (all adjusted p < 0.05). Importantly, serum miR-183-5p levels could predict the presence of CAD and 3-vessel or left main disease in the receiver operating characteristic curve analysis (both p < 0.01), and also in multivariate analysis adjusting for age, sex, body mass index, diabetes, hypersensitive-C-reactive protein (both p < 0.05). CONCLUSION: Serum miR-183-5p levels are independently and positively correlated with CAD presence and severity. Frontiers Media S.A. 2023-06-15 /pmc/articles/PMC10313402/ /pubmed/37396583 http://dx.doi.org/10.3389/fcvm.2023.1196348 Text en © 2023 Lv, Guo, Zhang, Li and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Lv, Dong Guo, Yanfu Zhang, Li Li, Xia Li, Guangping Circulating miR-183-5p levels are positively associated with the presence and severity of coronary artery disease |
title | Circulating miR-183-5p levels are positively associated with the presence and severity of coronary artery disease |
title_full | Circulating miR-183-5p levels are positively associated with the presence and severity of coronary artery disease |
title_fullStr | Circulating miR-183-5p levels are positively associated with the presence and severity of coronary artery disease |
title_full_unstemmed | Circulating miR-183-5p levels are positively associated with the presence and severity of coronary artery disease |
title_short | Circulating miR-183-5p levels are positively associated with the presence and severity of coronary artery disease |
title_sort | circulating mir-183-5p levels are positively associated with the presence and severity of coronary artery disease |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313402/ https://www.ncbi.nlm.nih.gov/pubmed/37396583 http://dx.doi.org/10.3389/fcvm.2023.1196348 |
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