The antidepressant imipramine inhibits breast cancer growth by targeting estrogen receptor signaling and DNA repair events

Aberrant activities of various cell cycle and DNA repair proteins promote cancer growth and progression and render them resistant to therapies. Here, we demonstrate that the anti-depressant imipramine blocks growth of triple-negative (TNBC) and estrogen receptor-positive (ER+) breast cancers by indu...

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Detalles Bibliográficos
Autores principales: Timilsina, Santosh, Rajamanickam, Subapriya, Rao, Arhan, Subbarayalu, Panneerdoss, Nirzhor, Saif, Abdelfattah, Nourhan, Viswanadhapalli, Suryavathi, Chen, Yidong, Jatoi, Ismail, Brenner, Andrew, Rao, Manjeet K., Vadlamudi, Ratna, Kaklamani, Virginia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313451/
https://www.ncbi.nlm.nih.gov/pubmed/35568265
http://dx.doi.org/10.1016/j.canlet.2022.215717

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