The Spliceosome Factor EFTUD2 Promotes IFN Anti-HBV Effect through mRNA Splicing

METHODS: Using a CRISPR/Cas9 gene-editing system, EFTUD2 single allele knockout HepG2.2.15 cells were constructed. Subsequently, the HBV biomarkers in EFTUD2(+/–) HepG2.2.15 cells and wild-type (WT) cells with or without IFN-α treatment were detected. And the EFTUD2-regulated genes were then identif...

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Detalles Bibliográficos
Autores principales: Hu, Pingping, Li, Yuwen, Zhang, Wen, Liu, Rui, Peng, Linya, Xu, Ruirui, Cai, Jinyuan, Yuan, Hui, Feng, Tiantong, Tian, Anran, Yue, Ming, Li, Jun, Li, Wenting, Zhu, Chuanlong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313468/
https://www.ncbi.nlm.nih.gov/pubmed/37396299
http://dx.doi.org/10.1155/2023/2546278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313468/
https://www.ncbi.nlm.nih.gov/pubmed/37396299
http://dx.doi.org/10.1155/2023/2546278

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