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In vivo co-registered hybrid-contrast imaging by successive photoacoustic tomography and magnetic resonance imaging
Magnetic resonance imaging (MRI) and photoacoustic tomography (PAT) offer two distinct image contrasts. To integrate these two modalities, we present a comprehensive hardware-software solution for the successive acquisition and co-registration of PAT and MRI images in in vivo animal studies. Based o...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313508/ https://www.ncbi.nlm.nih.gov/pubmed/37397508 http://dx.doi.org/10.1016/j.pacs.2023.100506 |
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author | Zhang, Shuangyang Liang, Zhichao Tang, Kaiyi Li, Xipan Zhang, Xiaoming Mo, Zongxin Wu, Jian Huang, Shixian Liu, Jiaming Zhuang, Zhijian Qi, Li Chen, Wufan |
author_facet | Zhang, Shuangyang Liang, Zhichao Tang, Kaiyi Li, Xipan Zhang, Xiaoming Mo, Zongxin Wu, Jian Huang, Shixian Liu, Jiaming Zhuang, Zhijian Qi, Li Chen, Wufan |
author_sort | Zhang, Shuangyang |
collection | PubMed |
description | Magnetic resonance imaging (MRI) and photoacoustic tomography (PAT) offer two distinct image contrasts. To integrate these two modalities, we present a comprehensive hardware-software solution for the successive acquisition and co-registration of PAT and MRI images in in vivo animal studies. Based on commercial PAT and MRI scanners, our solution includes a 3D-printed dual-modality imaging bed, a 3-D spatial image co-registration algorithm with dual-modality markers, and a robust modality switching protocol for in vivo imaging studies. Using the proposed solution, we successfully demonstrated co-registered hybrid-contrast PAT-MRI imaging that simultaneously displays multi-scale anatomical, functional and molecular characteristics on healthy and cancerous living mice. Week-long longitudinal dual-modality imaging of tumor development reveals information on size, border, vascular pattern, blood oxygenation, and molecular probe metabolism of the tumor micro-environment at the same time. The proposed methodology holds promise for a wide range of pre-clinical research applications that benefit from the PAT-MRI dual-modality image contrast. |
format | Online Article Text |
id | pubmed-10313508 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-103135082023-07-02 In vivo co-registered hybrid-contrast imaging by successive photoacoustic tomography and magnetic resonance imaging Zhang, Shuangyang Liang, Zhichao Tang, Kaiyi Li, Xipan Zhang, Xiaoming Mo, Zongxin Wu, Jian Huang, Shixian Liu, Jiaming Zhuang, Zhijian Qi, Li Chen, Wufan Photoacoustics Research Article Magnetic resonance imaging (MRI) and photoacoustic tomography (PAT) offer two distinct image contrasts. To integrate these two modalities, we present a comprehensive hardware-software solution for the successive acquisition and co-registration of PAT and MRI images in in vivo animal studies. Based on commercial PAT and MRI scanners, our solution includes a 3D-printed dual-modality imaging bed, a 3-D spatial image co-registration algorithm with dual-modality markers, and a robust modality switching protocol for in vivo imaging studies. Using the proposed solution, we successfully demonstrated co-registered hybrid-contrast PAT-MRI imaging that simultaneously displays multi-scale anatomical, functional and molecular characteristics on healthy and cancerous living mice. Week-long longitudinal dual-modality imaging of tumor development reveals information on size, border, vascular pattern, blood oxygenation, and molecular probe metabolism of the tumor micro-environment at the same time. The proposed methodology holds promise for a wide range of pre-clinical research applications that benefit from the PAT-MRI dual-modality image contrast. Elsevier 2023-05-08 /pmc/articles/PMC10313508/ /pubmed/37397508 http://dx.doi.org/10.1016/j.pacs.2023.100506 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Research Article Zhang, Shuangyang Liang, Zhichao Tang, Kaiyi Li, Xipan Zhang, Xiaoming Mo, Zongxin Wu, Jian Huang, Shixian Liu, Jiaming Zhuang, Zhijian Qi, Li Chen, Wufan In vivo co-registered hybrid-contrast imaging by successive photoacoustic tomography and magnetic resonance imaging |
title | In vivo co-registered hybrid-contrast imaging by successive photoacoustic tomography and magnetic resonance imaging |
title_full | In vivo co-registered hybrid-contrast imaging by successive photoacoustic tomography and magnetic resonance imaging |
title_fullStr | In vivo co-registered hybrid-contrast imaging by successive photoacoustic tomography and magnetic resonance imaging |
title_full_unstemmed | In vivo co-registered hybrid-contrast imaging by successive photoacoustic tomography and magnetic resonance imaging |
title_short | In vivo co-registered hybrid-contrast imaging by successive photoacoustic tomography and magnetic resonance imaging |
title_sort | in vivo co-registered hybrid-contrast imaging by successive photoacoustic tomography and magnetic resonance imaging |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313508/ https://www.ncbi.nlm.nih.gov/pubmed/37397508 http://dx.doi.org/10.1016/j.pacs.2023.100506 |
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