RNF8 enhances the sensitivity of PD-L1 inhibitor against melanoma through ubiquitination of galectin-3 in stroma

The failure of melanoma immunotherapy can be mediated by immunosuppression in the tumor microenvironment (TME), and insufficient activation of effector T cells against the tumor. Here, we show that inhibition of galectin-3 (gal-3) enhances the infiltration of T cells in TME and improves the sensitiv...

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Detalles Bibliográficos
Autores principales: Guo, Yanan, Shen, Rong, Yang, Keren, Wang, Yutong, Song, Haoyun, Liu, Xiangwen, Cheng, Xin, Wu, Rile, Song, Yanfeng, Wang, Degui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313721/
https://www.ncbi.nlm.nih.gov/pubmed/37391451
http://dx.doi.org/10.1038/s41420-023-01500-3

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