The TNFR1 antagonist Atrosimab reduces neuronal loss, glial activation and memory deficits in an acute mouse model of neurodegeneration

Tumor necrosis factor alpha (TNF-α) and its key role in modulating immune responses has been widely recognized as a therapeutic target for inflammatory and neurodegenerative diseases. Even though inhibition of TNF-α is beneficial for the treatment of certain inflammatory diseases, total neutralizati...

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Detalles Bibliográficos
Autores principales: Ortí-Casañ, Natalia, Boerema, Ate S., Köpke, Karina, Ebskamp, Amber, Keijser, Jan, Zhang, Yuequ, Chen, Tingting, Dolga, Amalia M., Broersen, Kerensa, Fischer, Roman, Pfizenmaier, Klaus, Kontermann, Roland E., Eisel, Ulrich L. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313728/
https://www.ncbi.nlm.nih.gov/pubmed/37391534
http://dx.doi.org/10.1038/s41598-023-36846-2

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