TRPA1 activation in non-sensory supporting cells contributes to regulation of cochlear sensitivity after acoustic trauma

TRPA1 channels are expressed in nociceptive neurons, where they detect noxious stimuli, and in the mammalian cochlea, where their function is unknown. Here we show that TRPA1 activation in the supporting non-sensory Hensen’s cells of the mouse cochlea causes prolonged Ca(2+) responses, which propaga...

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Detalles Bibliográficos
Autores principales: Vélez-Ortega, A. Catalina, Stepanyan, Ruben, Edelmann, Stephanie E., Torres-Gallego, Sara, Park, Channy, Marinkova, Desislava A., Nowacki, Joshua S., Sinha, Ghanshyam P., Frolenkov, Gregory I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313773/
https://www.ncbi.nlm.nih.gov/pubmed/37391431
http://dx.doi.org/10.1038/s41467-023-39589-w

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