Drug reinforcement impairs cognitive flexibility by inhibiting striatal cholinergic neurons

Addictive substance use impairs cognitive flexibility, with unclear underlying mechanisms. The reinforcement of substance use is mediated by the striatal direct-pathway medium spiny neurons (dMSNs) that project to the substantia nigra pars reticulata (SNr). Cognitive flexibility is mediated by stria...

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Detalles Bibliográficos
Autores principales: Gangal, Himanshu, Xie, Xueyi, Huang, Zhenbo, Cheng, Yifeng, Wang, Xuehua, Lu, Jiayi, Zhuang, Xiaowen, Essoh, Amanda, Huang, Yufei, Chen, Ruifeng, Smith, Laura N., Smith, Rachel J., Wang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313783/
https://www.ncbi.nlm.nih.gov/pubmed/37391566
http://dx.doi.org/10.1038/s41467-023-39623-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313783/
https://www.ncbi.nlm.nih.gov/pubmed/37391566
http://dx.doi.org/10.1038/s41467-023-39623-x

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