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Drug reinforcement impairs cognitive flexibility by inhibiting striatal cholinergic neurons
Addictive substance use impairs cognitive flexibility, with unclear underlying mechanisms. The reinforcement of substance use is mediated by the striatal direct-pathway medium spiny neurons (dMSNs) that project to the substantia nigra pars reticulata (SNr). Cognitive flexibility is mediated by stria...
Autores principales: | Gangal, Himanshu, Xie, Xueyi, Huang, Zhenbo, Cheng, Yifeng, Wang, Xuehua, Lu, Jiayi, Zhuang, Xiaowen, Essoh, Amanda, Huang, Yufei, Chen, Ruifeng, Smith, Laura N., Smith, Rachel J., Wang, Jun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313783/ https://www.ncbi.nlm.nih.gov/pubmed/37391566 http://dx.doi.org/10.1038/s41467-023-39623-x |
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