Steering CAR T cell epigenetic programs by tweaking manufacturing protocol

CAR T cell persistence remains a significant roadblock to effective clinical translation of CAR T cells for solid and brain tumors. Jung et al.(1) demonstrate enrichment of resident memory phenotypes through simple changes to the CAR T cell manufacturing process.

Detalles Bibliográficos
Autores principales: Dukes, Meghan W., Krenciute, Giedre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Preview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313927/
https://www.ncbi.nlm.nih.gov/pubmed/37343521
http://dx.doi.org/10.1016/j.xcrm.2023.101080
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author Dukes, Meghan W.
Krenciute, Giedre
author_facet Dukes, Meghan W.
Krenciute, Giedre
author_sort Dukes, Meghan W.
collection PubMed
description CAR T cell persistence remains a significant roadblock to effective clinical translation of CAR T cells for solid and brain tumors. Jung et al.(1) demonstrate enrichment of resident memory phenotypes through simple changes to the CAR T cell manufacturing process.
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spelling pubmed-103139272023-07-02 Steering CAR T cell epigenetic programs by tweaking manufacturing protocol Dukes, Meghan W. Krenciute, Giedre Cell Rep Med Preview CAR T cell persistence remains a significant roadblock to effective clinical translation of CAR T cells for solid and brain tumors. Jung et al.(1) demonstrate enrichment of resident memory phenotypes through simple changes to the CAR T cell manufacturing process. Elsevier 2023-06-20 /pmc/articles/PMC10313927/ /pubmed/37343521 http://dx.doi.org/10.1016/j.xcrm.2023.101080 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Preview
Dukes, Meghan W.
Krenciute, Giedre
Steering CAR T cell epigenetic programs by tweaking manufacturing protocol
title Steering CAR T cell epigenetic programs by tweaking manufacturing protocol
title_full Steering CAR T cell epigenetic programs by tweaking manufacturing protocol
title_fullStr Steering CAR T cell epigenetic programs by tweaking manufacturing protocol
title_full_unstemmed Steering CAR T cell epigenetic programs by tweaking manufacturing protocol
title_short Steering CAR T cell epigenetic programs by tweaking manufacturing protocol
title_sort steering car t cell epigenetic programs by tweaking manufacturing protocol
topic Preview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313927/
https://www.ncbi.nlm.nih.gov/pubmed/37343521
http://dx.doi.org/10.1016/j.xcrm.2023.101080
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