Targeted deprivation of methionine with engineered Salmonella leads to oncolysis and suppression of metastasis in broad types of animal tumor models

The strong dependency of almost all malignant tumors on methionine potentially offers a pathway for cancer treatment. We engineer an attenuated strain of Salmonella typhimurium to overexpress an L-methioninase with the aim of specifically depriving tumor tissues of methionine. The engineered microbe...

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Detalles Bibliográficos
Autores principales: Zhou, Sujin, Lin, Yan, Zhao, Zhenggang, Lai, Yunhao, Lu, Mengmeng, Shao, Zishen, Mo, Xinyu, Mu, Yunping, Liang, Zhipeng, Wang, Xinxing, Qu, Jingming, Shen, Hua, Li, Fanghong, Zhao, Allan Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313934/
https://www.ncbi.nlm.nih.gov/pubmed/37269826
http://dx.doi.org/10.1016/j.xcrm.2023.101070

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