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Nitrous oxide-induced subacute combined degeneration of the cord: diagnosis and treatment

Recreational use of nitrous oxide (N(2)O) has increased rapidly in recent years and is now the second most commonly used recreational drug among young people in the UK. There has been a corresponding rise in cases of nitrous oxide-induced subacute combined degeneration of the cord (N(2)O-SACD), a pa...

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Autores principales: Paris, Alvar, Lake, Luke, Joseph, Albert, Workman, Anna, Walton, Joseph, Hayton, Tom, Evangelou, Nikos, Lilleker, James B, Ayling, Ruth M, Nicholl, David, Noyce, Alastair J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313972/
https://www.ncbi.nlm.nih.gov/pubmed/36813556
http://dx.doi.org/10.1136/pn-2022-003631
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author Paris, Alvar
Lake, Luke
Joseph, Albert
Workman, Anna
Walton, Joseph
Hayton, Tom
Evangelou, Nikos
Lilleker, James B
Ayling, Ruth M
Nicholl, David
Noyce, Alastair J
author_facet Paris, Alvar
Lake, Luke
Joseph, Albert
Workman, Anna
Walton, Joseph
Hayton, Tom
Evangelou, Nikos
Lilleker, James B
Ayling, Ruth M
Nicholl, David
Noyce, Alastair J
author_sort Paris, Alvar
collection PubMed
description Recreational use of nitrous oxide (N(2)O) has increased rapidly in recent years and is now the second most commonly used recreational drug among young people in the UK. There has been a corresponding rise in cases of nitrous oxide-induced subacute combined degeneration of the cord (N(2)O-SACD), a pattern of myeloneuropathy usually associated with severe vitamin B(12) deficiency. This can cause serious and permanent disability in young people but, if recognised early, may be effectively treated. All neurologists should be aware of N(2)O-SACD and its treatment; however, there are currently no agreed guidelines. Based on our experience in East London, an area of high N(2)O use, we provide practical advice on its recognition, investigation and treatment.
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spelling pubmed-103139722023-07-02 Nitrous oxide-induced subacute combined degeneration of the cord: diagnosis and treatment Paris, Alvar Lake, Luke Joseph, Albert Workman, Anna Walton, Joseph Hayton, Tom Evangelou, Nikos Lilleker, James B Ayling, Ruth M Nicholl, David Noyce, Alastair J Pract Neurol How to Do It Recreational use of nitrous oxide (N(2)O) has increased rapidly in recent years and is now the second most commonly used recreational drug among young people in the UK. There has been a corresponding rise in cases of nitrous oxide-induced subacute combined degeneration of the cord (N(2)O-SACD), a pattern of myeloneuropathy usually associated with severe vitamin B(12) deficiency. This can cause serious and permanent disability in young people but, if recognised early, may be effectively treated. All neurologists should be aware of N(2)O-SACD and its treatment; however, there are currently no agreed guidelines. Based on our experience in East London, an area of high N(2)O use, we provide practical advice on its recognition, investigation and treatment. BMJ Publishing Group 2023-06 2023-02-22 /pmc/articles/PMC10313972/ /pubmed/36813556 http://dx.doi.org/10.1136/pn-2022-003631 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle How to Do It
Paris, Alvar
Lake, Luke
Joseph, Albert
Workman, Anna
Walton, Joseph
Hayton, Tom
Evangelou, Nikos
Lilleker, James B
Ayling, Ruth M
Nicholl, David
Noyce, Alastair J
Nitrous oxide-induced subacute combined degeneration of the cord: diagnosis and treatment
title Nitrous oxide-induced subacute combined degeneration of the cord: diagnosis and treatment
title_full Nitrous oxide-induced subacute combined degeneration of the cord: diagnosis and treatment
title_fullStr Nitrous oxide-induced subacute combined degeneration of the cord: diagnosis and treatment
title_full_unstemmed Nitrous oxide-induced subacute combined degeneration of the cord: diagnosis and treatment
title_short Nitrous oxide-induced subacute combined degeneration of the cord: diagnosis and treatment
title_sort nitrous oxide-induced subacute combined degeneration of the cord: diagnosis and treatment
topic How to Do It
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313972/
https://www.ncbi.nlm.nih.gov/pubmed/36813556
http://dx.doi.org/10.1136/pn-2022-003631
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