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Incident cardiovascular events and imaging phenotypes in UK Biobank participants with past cancer

OBJECTIVES: To evaluate incident cardiovascular outcomes and imaging phenotypes in UK Biobank participants with previous cancer. METHODS: Cancer and cardiovascular disease (CVD) diagnoses were ascertained using health record linkage. Participants with cancer history (breast, lung, prostate, colorect...

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Autores principales: Raisi-Estabragh, Zahra, Cooper, Jackie, McCracken, Celeste, Crosbie, Emma J, Walter, Fiona M, Manisty, Charlotte H, Robson, John, Mamas, Mamas A, Harvey, Nicholas C, Neubauer, Stefan, Petersen, Steffen E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314020/
https://www.ncbi.nlm.nih.gov/pubmed/37072241
http://dx.doi.org/10.1136/heartjnl-2022-321888
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author Raisi-Estabragh, Zahra
Cooper, Jackie
McCracken, Celeste
Crosbie, Emma J
Walter, Fiona M
Manisty, Charlotte H
Robson, John
Mamas, Mamas A
Harvey, Nicholas C
Neubauer, Stefan
Petersen, Steffen E
author_facet Raisi-Estabragh, Zahra
Cooper, Jackie
McCracken, Celeste
Crosbie, Emma J
Walter, Fiona M
Manisty, Charlotte H
Robson, John
Mamas, Mamas A
Harvey, Nicholas C
Neubauer, Stefan
Petersen, Steffen E
author_sort Raisi-Estabragh, Zahra
collection PubMed
description OBJECTIVES: To evaluate incident cardiovascular outcomes and imaging phenotypes in UK Biobank participants with previous cancer. METHODS: Cancer and cardiovascular disease (CVD) diagnoses were ascertained using health record linkage. Participants with cancer history (breast, lung, prostate, colorectal, uterus, haematological) were propensity matched on vascular risk factors to non-cancer controls. Competing risk regression was used to calculate subdistribution HRs (SHRs) for associations of cancer history with incident CVD (ischaemic heart disease (IHD), non-ischaemic cardiomyopathy (NICM), heart failure (HF), atrial fibrillation/flutter, stroke, pericarditis, venous thromboembolism (VTE)) and mortality outcomes (any CVD, IHD, HF/NICM, stroke, hypertensive disease) over 11.8±1.7 years of prospective follow-up. Linear regression was used to assess associations of cancer history with left ventricular (LV) and left atrial metrics. RESULTS: We studied 18 714 participants (67% women, age: 62 (IQR: 57–66) years, 97% white ethnicities) with cancer history, including 1354 individuals with cardiovascular magnetic resonance. Participants with cancer had high burden of vascular risk factors and prevalent CVDs. Haematological cancer was associated with increased risk of all incident CVDs considered (SHRs: 1.92–3.56), larger chamber volumes, lower ejection fractions, and poorer LV strain. Breast cancer was associated with increased risk of selected CVDs (NICM, HF, pericarditis and VTE; SHRs: 1.34–2.03), HF/NICM death, hypertensive disease death, lower LV ejection fraction, and lower LV global function index. Lung cancer was associated with increased risk of pericarditis, HF, and CVD death. Prostate cancer was linked to increased VTE risk. CONCLUSIONS: Cancer history is linked to increased risk of incident CVDs and adverse cardiac remodelling independent of shared vascular risk factors.
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spelling pubmed-103140202023-07-02 Incident cardiovascular events and imaging phenotypes in UK Biobank participants with past cancer Raisi-Estabragh, Zahra Cooper, Jackie McCracken, Celeste Crosbie, Emma J Walter, Fiona M Manisty, Charlotte H Robson, John Mamas, Mamas A Harvey, Nicholas C Neubauer, Stefan Petersen, Steffen E Heart Cardiac Risk Factors and Prevention OBJECTIVES: To evaluate incident cardiovascular outcomes and imaging phenotypes in UK Biobank participants with previous cancer. METHODS: Cancer and cardiovascular disease (CVD) diagnoses were ascertained using health record linkage. Participants with cancer history (breast, lung, prostate, colorectal, uterus, haematological) were propensity matched on vascular risk factors to non-cancer controls. Competing risk regression was used to calculate subdistribution HRs (SHRs) for associations of cancer history with incident CVD (ischaemic heart disease (IHD), non-ischaemic cardiomyopathy (NICM), heart failure (HF), atrial fibrillation/flutter, stroke, pericarditis, venous thromboembolism (VTE)) and mortality outcomes (any CVD, IHD, HF/NICM, stroke, hypertensive disease) over 11.8±1.7 years of prospective follow-up. Linear regression was used to assess associations of cancer history with left ventricular (LV) and left atrial metrics. RESULTS: We studied 18 714 participants (67% women, age: 62 (IQR: 57–66) years, 97% white ethnicities) with cancer history, including 1354 individuals with cardiovascular magnetic resonance. Participants with cancer had high burden of vascular risk factors and prevalent CVDs. Haematological cancer was associated with increased risk of all incident CVDs considered (SHRs: 1.92–3.56), larger chamber volumes, lower ejection fractions, and poorer LV strain. Breast cancer was associated with increased risk of selected CVDs (NICM, HF, pericarditis and VTE; SHRs: 1.34–2.03), HF/NICM death, hypertensive disease death, lower LV ejection fraction, and lower LV global function index. Lung cancer was associated with increased risk of pericarditis, HF, and CVD death. Prostate cancer was linked to increased VTE risk. CONCLUSIONS: Cancer history is linked to increased risk of incident CVDs and adverse cardiac remodelling independent of shared vascular risk factors. BMJ Publishing Group 2023-07 2023-04-18 /pmc/articles/PMC10314020/ /pubmed/37072241 http://dx.doi.org/10.1136/heartjnl-2022-321888 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Cardiac Risk Factors and Prevention
Raisi-Estabragh, Zahra
Cooper, Jackie
McCracken, Celeste
Crosbie, Emma J
Walter, Fiona M
Manisty, Charlotte H
Robson, John
Mamas, Mamas A
Harvey, Nicholas C
Neubauer, Stefan
Petersen, Steffen E
Incident cardiovascular events and imaging phenotypes in UK Biobank participants with past cancer
title Incident cardiovascular events and imaging phenotypes in UK Biobank participants with past cancer
title_full Incident cardiovascular events and imaging phenotypes in UK Biobank participants with past cancer
title_fullStr Incident cardiovascular events and imaging phenotypes in UK Biobank participants with past cancer
title_full_unstemmed Incident cardiovascular events and imaging phenotypes in UK Biobank participants with past cancer
title_short Incident cardiovascular events and imaging phenotypes in UK Biobank participants with past cancer
title_sort incident cardiovascular events and imaging phenotypes in uk biobank participants with past cancer
topic Cardiac Risk Factors and Prevention
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314020/
https://www.ncbi.nlm.nih.gov/pubmed/37072241
http://dx.doi.org/10.1136/heartjnl-2022-321888
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