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Proteinase 3 promotes formation of multinucleated giant cells and granuloma-like structures in patients with granulomatosis with polyangiitis

OBJECTIVES: Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are autoimmune vasculitides associated with antineutrophil cytoplasm antibodies that target proteinase 3 (PR3) or myeloperoxidase (MPO) found within neutrophils and monocytes. Granulomas are exclusively found in GP...

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Detalles Bibliográficos
Autores principales:	Henderson, Scott R, Horsley, Harry, Frankel, Paul, Khosravi, Maryam, Goble, Talya, Carter, Stephen, Antonelou, Marilina, Evans, Rhys D R, Zhang, Xiang, Chu, Tai-Ying, Lin, Hsi-Hsien, Gordon, Siamon, Salama, Alan David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2023
Materias:	Vasculitis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314067/ https://www.ncbi.nlm.nih.gov/pubmed/36801813 http://dx.doi.org/10.1136/ard-2021-221800

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