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Gut microbiota in brain tumors: An emerging crucial player

In recent decades, various roles of the gut microbiota in physiological and pathological conditions have been uncovered. Among the many interacting pathways between the host and gut flora, the gut–brain axis has drawn increasing attention and is generally considered a promising way to understand and...

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Autores principales: Lin, Ben, Ye, Zhen, Ye, Zhao, Wang, Meng, Cao, Zhan, Gao, Renyuan, Zhang, Yichao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314108/
https://www.ncbi.nlm.nih.gov/pubmed/36627748
http://dx.doi.org/10.1111/cns.14081
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author Lin, Ben
Ye, Zhen
Ye, Zhao
Wang, Meng
Cao, Zhan
Gao, Renyuan
Zhang, Yichao
author_facet Lin, Ben
Ye, Zhen
Ye, Zhao
Wang, Meng
Cao, Zhan
Gao, Renyuan
Zhang, Yichao
author_sort Lin, Ben
collection PubMed
description In recent decades, various roles of the gut microbiota in physiological and pathological conditions have been uncovered. Among the many interacting pathways between the host and gut flora, the gut–brain axis has drawn increasing attention and is generally considered a promising way to understand and treat brain tumors, one of the most lethal neoplasms. In this narrative review, we aimed to unveil and dissect the sophisticated mechanisms by which the gut‐brain axis exerts its influence on brain tumors. Furthermore, we summarized the latest research regarding the gastrointestinal microbial landscape and the effect of gut–brain axis malfunction on different brain tumors. Finally, we outlined the ongoing developing approaches of microbial manipulation and their corresponding research related to neuro‐malignancies. Collectively, we recapitulated the advances in gut microbial alterations along with their potential interactive mechanisms in brain tumors and encouraged increased efforts in this area.
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spelling pubmed-103141082023-07-02 Gut microbiota in brain tumors: An emerging crucial player Lin, Ben Ye, Zhen Ye, Zhao Wang, Meng Cao, Zhan Gao, Renyuan Zhang, Yichao CNS Neurosci Ther Review In recent decades, various roles of the gut microbiota in physiological and pathological conditions have been uncovered. Among the many interacting pathways between the host and gut flora, the gut–brain axis has drawn increasing attention and is generally considered a promising way to understand and treat brain tumors, one of the most lethal neoplasms. In this narrative review, we aimed to unveil and dissect the sophisticated mechanisms by which the gut‐brain axis exerts its influence on brain tumors. Furthermore, we summarized the latest research regarding the gastrointestinal microbial landscape and the effect of gut–brain axis malfunction on different brain tumors. Finally, we outlined the ongoing developing approaches of microbial manipulation and their corresponding research related to neuro‐malignancies. Collectively, we recapitulated the advances in gut microbial alterations along with their potential interactive mechanisms in brain tumors and encouraged increased efforts in this area. John Wiley and Sons Inc. 2023-01-10 /pmc/articles/PMC10314108/ /pubmed/36627748 http://dx.doi.org/10.1111/cns.14081 Text en © 2023 The Authors. CNS Neuroscience & Therapeutics Published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Lin, Ben
Ye, Zhen
Ye, Zhao
Wang, Meng
Cao, Zhan
Gao, Renyuan
Zhang, Yichao
Gut microbiota in brain tumors: An emerging crucial player
title Gut microbiota in brain tumors: An emerging crucial player
title_full Gut microbiota in brain tumors: An emerging crucial player
title_fullStr Gut microbiota in brain tumors: An emerging crucial player
title_full_unstemmed Gut microbiota in brain tumors: An emerging crucial player
title_short Gut microbiota in brain tumors: An emerging crucial player
title_sort gut microbiota in brain tumors: an emerging crucial player
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314108/
https://www.ncbi.nlm.nih.gov/pubmed/36627748
http://dx.doi.org/10.1111/cns.14081
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