Haploinsufficiency of NFKBIA reshapes the epigenome antipodal to the IDH mutation and imparts disease fate in diffuse gliomas

Genetic alterations help predict the clinical behavior of diffuse gliomas, but some variability remains uncorrelated. Here, we demonstrate that haploinsufficient deletions of chromatin-bound tumor suppressor NFKB inhibitor alpha (NFKBIA) display distinct patterns of occurrence in relation to other g...

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Detalles Bibliográficos
Autores principales: Bredel, Markus, Espinosa, Lluís, Kim, Hyunsoo, Scholtens, Denise M., McElroy, Joseph P., Rajbhandari, Rajani, Meng, Wei, Kollmeyer, Thomas M., Malta, Tathiane M., Quezada, Michael A., Harsh, Griffith R., Lobo-Jarne, Teresa, Solé, Laura, Merati, Aran, Nagaraja, Surya, Nair, Sindhu, White, Jaclyn J., Thudi, Nanda K., Fleming, Jessica L., Webb, Amy, Natsume, Atsushi, Ogawa, Seishi, Weber, Ruthild G., Bertran, Joan, Haque, S. Jaharul, Hentschel, Bettina, Miller, C. Ryan, Furnari, Frank B., Chan, Timothy A., Grosu, Anca-Ligia, Weller, Michael, Barnholtz-Sloan, Jill S., Monje, Michelle, Noushmehr, Houtan, Jenkins, Robert B., Rogers, C. Leland, MacDonald, David R., Pugh, Stephanie L., Chakravarti, Arnab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314122/
https://www.ncbi.nlm.nih.gov/pubmed/37343523
http://dx.doi.org/10.1016/j.xcrm.2023.101082

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