Dual-targeting inhibition of TNFR1 for alleviating rheumatoid arthritis by a novel composite nucleic acid nanodrug

Selective suppression of tumor necrosis factor (TNF) α-TNF receptor 1 (TNFR1) signaling is a potent solution for rheumatoid arthritis (RA). Herein, novel composite nucleic acid nanodrugs that simultaneously restrain TNF α binding and TNFR1 multimerization were designed to reinforce inhibition of TNF...

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Detalles Bibliográficos
Autores principales: Wang, Xiaonan, Guo, Fanfan, Zhang, Yi, Wang, Ziyi, Wang, Jiaqi, Luo, Rongrong, Chu, Xiao, Zhao, Yongxing, Sun, Pengchao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314200/
https://www.ncbi.nlm.nih.gov/pubmed/37396624
http://dx.doi.org/10.1016/j.ijpx.2023.100162

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