CD200 in dentate gyrus improves depressive-like behaviors of mice through enhancing hippocampal neurogenesis via alleviation of microglia hyperactivation

BACKGROUND: Neuroinflammation and microglia play critical roles in the development of depression. Cluster of differentiation 200 (CD200) is an anti-inflammatory glycoprotein that is mainly expressed in neurons, and its receptor CD200R1 is primarily in microglia. Although the CD200–CD200R1 pathway is...

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Detalles Bibliográficos
Autores principales: Chen, Xi, Cui, Qian-Qian, Hu, Xiao-Hai, Ye, Jian, Liu, Zi-Cun, Mei, Yuan-Xi, Wang, Fang, Hu, Zhuang-Li, Chen, Jian-Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314496/
https://www.ncbi.nlm.nih.gov/pubmed/37391731
http://dx.doi.org/10.1186/s12974-023-02836-4

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