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Dynamic changes of DNA methylation induced by benzo(a)pyrene in cancer

Benzo(a)pyrene (BaP), the earliest and most significant carcinogen among polycyclic aromatic hydrocarbons (PAHs), has been found in foods, tobacco smoke, and automobiles exhaust, etc. Exposure to BaP induced DNA damage directly, or oxidative stress-related damage, resulting in cell apoptosis and car...

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Autores principales: Wang, Huizeng, Liu, Bingchun, Chen, Hong, Xu, Peixin, Xue, Huiting, Yuan, Jianlong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314634/
https://www.ncbi.nlm.nih.gov/pubmed/37391844
http://dx.doi.org/10.1186/s41021-023-00278-1
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author Wang, Huizeng
Liu, Bingchun
Chen, Hong
Xu, Peixin
Xue, Huiting
Yuan, Jianlong
author_facet Wang, Huizeng
Liu, Bingchun
Chen, Hong
Xu, Peixin
Xue, Huiting
Yuan, Jianlong
author_sort Wang, Huizeng
collection PubMed
description Benzo(a)pyrene (BaP), the earliest and most significant carcinogen among polycyclic aromatic hydrocarbons (PAHs), has been found in foods, tobacco smoke, and automobiles exhaust, etc. Exposure to BaP induced DNA damage directly, or oxidative stress-related damage, resulting in cell apoptosis and carcinogenesis in human respiratory system, digestive system, reproductive system, etc. Moreover, BaP triggered genome-wide epigenetic alterations by methylation, which might cause disturbances in regulation of gene expression, and thereby induced cancer. It has been proved that BaP reduced genome-wide DNA methylation, and activated proto-oncogene by hypomethylation in the promoter region, but silenced tumor suppressor genes by promoter hypermethylation, resulting in cancer initiation and progression. Here we summarized the changes in DNA methylation in BaP exposure, and revealed the methylation of DNA plays a role in cancer development. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-103146342023-07-02 Dynamic changes of DNA methylation induced by benzo(a)pyrene in cancer Wang, Huizeng Liu, Bingchun Chen, Hong Xu, Peixin Xue, Huiting Yuan, Jianlong Genes Environ Review Benzo(a)pyrene (BaP), the earliest and most significant carcinogen among polycyclic aromatic hydrocarbons (PAHs), has been found in foods, tobacco smoke, and automobiles exhaust, etc. Exposure to BaP induced DNA damage directly, or oxidative stress-related damage, resulting in cell apoptosis and carcinogenesis in human respiratory system, digestive system, reproductive system, etc. Moreover, BaP triggered genome-wide epigenetic alterations by methylation, which might cause disturbances in regulation of gene expression, and thereby induced cancer. It has been proved that BaP reduced genome-wide DNA methylation, and activated proto-oncogene by hypomethylation in the promoter region, but silenced tumor suppressor genes by promoter hypermethylation, resulting in cancer initiation and progression. Here we summarized the changes in DNA methylation in BaP exposure, and revealed the methylation of DNA plays a role in cancer development. GRAPHICAL ABSTRACT: [Image: see text] BioMed Central 2023-07-01 /pmc/articles/PMC10314634/ /pubmed/37391844 http://dx.doi.org/10.1186/s41021-023-00278-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Wang, Huizeng
Liu, Bingchun
Chen, Hong
Xu, Peixin
Xue, Huiting
Yuan, Jianlong
Dynamic changes of DNA methylation induced by benzo(a)pyrene in cancer
title Dynamic changes of DNA methylation induced by benzo(a)pyrene in cancer
title_full Dynamic changes of DNA methylation induced by benzo(a)pyrene in cancer
title_fullStr Dynamic changes of DNA methylation induced by benzo(a)pyrene in cancer
title_full_unstemmed Dynamic changes of DNA methylation induced by benzo(a)pyrene in cancer
title_short Dynamic changes of DNA methylation induced by benzo(a)pyrene in cancer
title_sort dynamic changes of dna methylation induced by benzo(a)pyrene in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314634/
https://www.ncbi.nlm.nih.gov/pubmed/37391844
http://dx.doi.org/10.1186/s41021-023-00278-1
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