Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes

BACKGROUND: Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan-dioxygenase (TDO) are enzymes catabolizing the essential amino acid tryptophan into kynurenine. Expression of these enzymes is frequently observed in advanced-stage cancers and is associated with poor disease prognosis and immune suppre...

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Detalles Bibliográficos
Autores principales: Solvay, Marie, Holfelder, Pauline, Klaessens, Simon, Pilotte, Luc, Stroobant, Vincent, Lamy, Juliette, Naulaerts, Stefan, Spillier, Quentin, Frédérick, Raphaël, De Plaen, Etienne, Sers, Christine, Opitz, Christiane A, Van den Eynde, Benoit J, Zhu, Jingjing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314700/
https://www.ncbi.nlm.nih.gov/pubmed/37344101
http://dx.doi.org/10.1136/jitc-2023-006728

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