Hairy Cell Leukemia: Hepatic Affinity Status Post Splenectomy

Hairy cell leukemia (HCL) is a rare neoplasm of the B-cell lineage that is characterized by an indolent course and infiltration of the spleen, the bone marrow, and the reticuloendothelial system. Splenectomy is considered an effective treatment for peripheral cytopenia in patients with HCL. Hepatic...

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Detalles Bibliográficos
Autores principales: Dhanesar, Gurneel K, Livingston, Jonathan, Maroules, Michael, Lee, Sheue H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314737/
https://www.ncbi.nlm.nih.gov/pubmed/37397667
http://dx.doi.org/10.7759/cureus.39830
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author Dhanesar, Gurneel K
Livingston, Jonathan
Maroules, Michael
Lee, Sheue H
author_facet Dhanesar, Gurneel K
Livingston, Jonathan
Maroules, Michael
Lee, Sheue H
author_sort Dhanesar, Gurneel K
collection PubMed
description Hairy cell leukemia (HCL) is a rare neoplasm of the B-cell lineage that is characterized by an indolent course and infiltration of the spleen, the bone marrow, and the reticuloendothelial system. Splenectomy is considered an effective treatment for peripheral cytopenia in patients with HCL. Hepatic involvement of hairy cells with infiltration of the sinusoidal endothelial cells is rarely reported in the literature and is not well understood. We present the case of an 88-year-old male with a history of traumatic splenectomy who was found to have a relapse of classic hairy cell leukemia within the hepatic portal system.
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spelling pubmed-103147372023-07-02 Hairy Cell Leukemia: Hepatic Affinity Status Post Splenectomy Dhanesar, Gurneel K Livingston, Jonathan Maroules, Michael Lee, Sheue H Cureus Internal Medicine Hairy cell leukemia (HCL) is a rare neoplasm of the B-cell lineage that is characterized by an indolent course and infiltration of the spleen, the bone marrow, and the reticuloendothelial system. Splenectomy is considered an effective treatment for peripheral cytopenia in patients with HCL. Hepatic involvement of hairy cells with infiltration of the sinusoidal endothelial cells is rarely reported in the literature and is not well understood. We present the case of an 88-year-old male with a history of traumatic splenectomy who was found to have a relapse of classic hairy cell leukemia within the hepatic portal system. Cureus 2023-06-01 /pmc/articles/PMC10314737/ /pubmed/37397667 http://dx.doi.org/10.7759/cureus.39830 Text en Copyright © 2023, Dhanesar et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Dhanesar, Gurneel K
Livingston, Jonathan
Maroules, Michael
Lee, Sheue H
Hairy Cell Leukemia: Hepatic Affinity Status Post Splenectomy
title Hairy Cell Leukemia: Hepatic Affinity Status Post Splenectomy
title_full Hairy Cell Leukemia: Hepatic Affinity Status Post Splenectomy
title_fullStr Hairy Cell Leukemia: Hepatic Affinity Status Post Splenectomy
title_full_unstemmed Hairy Cell Leukemia: Hepatic Affinity Status Post Splenectomy
title_short Hairy Cell Leukemia: Hepatic Affinity Status Post Splenectomy
title_sort hairy cell leukemia: hepatic affinity status post splenectomy
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314737/
https://www.ncbi.nlm.nih.gov/pubmed/37397667
http://dx.doi.org/10.7759/cureus.39830
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AT livingstonjonathan hairycellleukemiahepaticaffinitystatuspostsplenectomy
AT maroulesmichael hairycellleukemiahepaticaffinitystatuspostsplenectomy
AT leesheueh hairycellleukemiahepaticaffinitystatuspostsplenectomy

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