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Trastuzumab Charge Variants: a Study on Physicochemical and Pharmacokinetic Properties

BACKGROUND: Post-translational modifications in bioprocessing and storage of recombinant mAbs are the main sources of charge variants. While the profile of these kinds of variants is considered an important quality attribute of therapeutic mAbs, there is controversy about their direct role on safety...

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Detalles Bibliográficos
Autores principales:	Torkashvand, Fatemeh, Mehranfar, Mahsa, Rashidi Gero, Mahsa, Jafarian, Parisa, Mirabzadeh, Esmat, Azarian, Bahareh, Sardari, Soroush, Vaziri, Behrouz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Pasteur Institute of Iran 2023
Materias:	Full Length
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314757/ https://www.ncbi.nlm.nih.gov/pubmed/37070702 http://dx.doi.org/10.52547/ibj.3837

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